| http://purl.uniprot.org/citations/19167760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19167760 | http://www.w3.org/2000/01/rdf-schema#comment | "The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. The anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen presenting cell populations, but it is also strongly up-regulated in lupus prone mice with active nephritis. In order to characterize the role of the C3aR in inflammatory nephritis, we bred C3aR knock out mice onto the MRL/lpr genetic background (C3aR KO MRL). Compared to control MRL/lpr mice, C3aR KO MRL mice had elevated auto-antibody titers and an earlier onset of renal injury. At 8 weeks, renal expression of a wide range of chemokines and chemokine receptors was increased in C3aR KO MRL kidneys compared to controls. Only the expression of MCP-1 was significantly decreased in the C3aR KO MRL mice. The increased chemokine and chemokine receptor expression seen in the C3aR KO MRL mice was associated with a more rapid rise in serum creatinine and the acceleration of renal fibrosis. However, loss of the C3aR had little impact on long-term kidney injury and did not alter survival. These findings suggest that activation of the C3aR plays a protective, not pathologic, role in the early phase of inflammatory nephritis in the MRL/lpr model of SLE."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2008.12.004"xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/author | "Wenderfer S.E."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/author | "Wetsel R.A."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/author | "Ke B."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/author | "Braun M.C."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/pages | "1397-1404"xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/title | "C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse."xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/19167760 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19167760 |
| http://purl.uniprot.org/citations/19167760 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19167760 |
| http://purl.uniprot.org/uniprot/#_O09047-mappedCitation-19167760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/#_Q5U7A4-mappedCitation-19167760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/#_Q3U4N3-mappedCitation-19167760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/#_Q8C6R2-mappedCitation-19167760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/Q3U4N3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/Q8C6R2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/O09047 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19167760 |
| http://purl.uniprot.org/uniprot/Q5U7A4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19167760 |