| http://purl.uniprot.org/citations/19168437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19168437 | http://www.w3.org/2000/01/rdf-schema#comment | "The migration of vascular smooth muscle cells (VSMCs) plays an essential role during the development of atherosclerosis and restenosis. Extensive studies have implicated the importance of extracellular matrix (ECM)-degrading proteinases in VSMC migration. A recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), is capable of degrading vascular ECM proteins. Here, we sought to determine whether ADAMTS-7 is involved in VSMC migration and neointima formation in response to vascular injury. ADAMTS-7 protein accumulated preferentially in neointima of the carotid artery wall after balloon injury. In primary VSMCs, ADAMTS-7 level was enhanced by the proinflammatory cytokine tumor necrosis factor alpha and growth factor platelet-derived growth factor-BB. ADAMTS-7 overexpression greatly accelerated and small interfering RNA knockdown markedly retarded VSMC migration/invasion in vitro. In addition, luminal delivery of ADAMTS-7 adenovirus to carotid arteries exacerbated intimal thickening nearly sixfold 7 days after injury. Conversely, perivascular administration of ADAMTS-7 small interfering RNA but not scramble small interfering RNA to injured arteries attenuated intimal thickening by 50% at 14 days after injury. Furthermore, ADAMTS-7 mediated degradation of the vascular ECM cartilage oligomeric matrix protein (COMP) in injured vessels. Replenishing COMP circumvented the promigratory effect of ADAMTS-7 on VSMCs. Enforced expression of COMP significantly suppressed VSMC migration and neointima formation postinjury, which indicates that ADAMTS-7 facilitated intimal hyperplasia through degradation of inhibitory matrix protein COMP. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and postangioplasty restenosis."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.org/dc/terms/identifier | "doi:10.1161/circresaha.108.188425"xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Kong W."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/author | "Liu C.J."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/pages | "688-698"xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/title | "ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries."xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/19168437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19168437 |
| http://purl.uniprot.org/citations/19168437 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19168437 |
| http://purl.uniprot.org/uniprot/#_A0A140TAF3-mappedCitation-19168437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19168437 |
| http://purl.uniprot.org/uniprot/#_A6I220-mappedCitation-19168437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19168437 |
| http://purl.uniprot.org/uniprot/#_Q1EHB3-mappedCitation-19168437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19168437 |
| http://purl.uniprot.org/uniprot/A6I220 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19168437 |
| http://purl.uniprot.org/uniprot/Q1EHB3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19168437 |