| http://purl.uniprot.org/citations/19170769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19170769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19170769 | http://www.w3.org/2000/01/rdf-schema#comment | "There is a class of GTPase activating proteins for the Rho family GTPases (RhoGAPs) that contain the steroidogenic acute regulatory protein (STAR)-related lipid transfer (START) domain. In mammals three genes encode such proteins and they are designated START-GAP1-3 or deleted in liver cancer 1-3 (DLC1-3). In this study, we examined the intracellular localization and roles of START-GAP1/DLC1 in cell motility. Immunofluorescence microscopic analysis of NRK cells and HeLa cells revealed that START-GAP1 was localized in focal adhesions. Amino acid residues 265-459 of START-GAP1 were found to be necessary for focal adhesion targeting and we name the region "the focal adhesion-targeting (FAT) domain." It was previously known that ectopic expression of START-GAP1 induced cell rounding. We demonstrated that the FAT domain of START-GAP1 was partially required for this morphological change. Furthermore, expression of this domain in HeLa cells resulted in dissociation of endogenous START-GAP1 from focal adhesions as a dominant negative modulator, reducing cell migration and spreading. Taken together, START-GAP1 is targeted to focal adhesions via the FAT domain and regulates actin rearrangement through down-regulation of active RhoA and Cdc42. Its absence from focal adhesions could, therefore, cause abnormal cell motility and spreading."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2008.01265.x"xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2008.01265.x"xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Hirata H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Hirata H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Homma Y."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Homma Y."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Yamaga M."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Yamaga M."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Yagisawa H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Yagisawa H."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Iwamae Y."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Iwamae Y."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Kiyota M."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/author | "Kiyota M."xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/19170769 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |