| http://purl.uniprot.org/citations/19170879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19170879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19170879 | http://www.w3.org/2000/01/rdf-schema#comment | "Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analysed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA). Both carbonyl compounds cause a stress response characteristic for thiol-reactive electrophiles as revealed by the induction of the Spx, CtsR, CymR, PerR, ArsR, CzrA, CsoR and SigmaD regulons. MG and FA triggered also a SOS response which indicates DNA damage. Protection against FA is mediated by both the hxlAB operon, encoding the ribulose monophosphate pathway for FA fixation, and a thiol-dependent formaldehyde dehydrogenase (AdhA) and DJ-1/PfpI-family cysteine proteinase (YraA). The adhA-yraA operon and the yraC gene, encoding a gamma-carboxymuconolactone decarboxylase, are positively regulated by the MerR-family regulator, YraB(AdhR). AdhR binds specifically to its target promoters which contain a 7-4-7 inverted repeat (CTTAAAG-N4-CTTTAAG) between the -35 and -10 elements. Activation of adhA-yraA transcription by AdhR requires the conserved Cys52 residue in vivo. We speculate that AdhR is redox-regulated via thiol-(S)-alkylation by aldehydes and that AdhA and YraA are specifically involved in reduction of aldehydes and degradation or repair of damaged thiol-containing proteins respectively."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2008.06568.x"xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2008.06568.x"xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Antelmann H."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Antelmann H."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Hecker M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Hecker M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Helmann J.D."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Helmann J.D."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Lalk M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Lalk M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Liebeke M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Liebeke M."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Maeder U."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Maeder U."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Eiamphungporn W."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Eiamphungporn W."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Nguyen T.T.H."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/author | "Nguyen T.T.H."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/19170879 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |