| http://purl.uniprot.org/citations/19171888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19171888 | http://www.w3.org/2000/01/rdf-schema#comment | "Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data supporting a role for selected mutually regulated genes in signal integration. Interestingly, Notch-RTK integration did not lead to general antagonism of either pathway, as is commonly believed. Instead, integration had a combinatorial effect on specific cross-regulated targets, which unexpectedly included numerous core components of the RTK and other major signaling pathways (TGF-beta, Hh, Jak/Stat, nuclear receptor and Wnt). We find the majority of Ras-responsive genes are also Notch-responsive, suggesting Notch may function to specify the response to Ras activation."xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0812024106"xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/author | "Artavanis-Tsakonas S."xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/author | "Kankel M.W."xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/author | "Hurlbut G.D."xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/pages | "2218-2223"xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/title | "Nodal points and complexity of Notch-Ras signal integration."xsd:string |
| http://purl.uniprot.org/citations/19171888 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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