| http://purl.uniprot.org/citations/19173313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19173313 | http://www.w3.org/2000/01/rdf-schema#comment | "Lewis X trisaccharides normally function as essential cell-cell interaction mediators. However, oligomers of Lewis X trisaccharides expressed by the parasite Schistosoma mansoni seem to be related to its evasion of the immune response of its human host. Here we show that monoclonal antibody 54-5C10-A, which is used to diagnose schistosomiasis in humans, interacts with oligomers of at least three Lewis X trisaccharides, but not with monomeric Lewis X. We describe the sequence and the 2.5 A crystal structure of its Fab fragment and infer a possible mode of binding of the polymeric Lewis X from docking studies. Our studies indicate a radically different mode of binding compared to Fab 291-2G3-A, which is specific for monomeric Lewis X, thus providing a structural explanation of the diagnostic success of 54-5C10-A."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.org/dc/terms/identifier | "doi:10.1002/prot.22356"xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "Abrahams J.P."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "Deelder A.M."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "van Roon A.M."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "Thomassen E.A."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "de Geus D.C."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/author | "Hokke C.H."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/name | "Proteins"xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/pages | "439-447"xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/title | "Characterization of a diagnostic Fab fragment binding trimeric Lewis X."xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/19173313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19173313 |
| http://purl.uniprot.org/citations/19173313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19173313 |
| http://purl.uniprot.org/uniprot/#_P01631-mappedCitation-19173313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19173313 |
| http://purl.uniprot.org/uniprot/#_P01837-mappedCitation-19173313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19173313 |
| http://purl.uniprot.org/uniprot/#_P03987-mappedCitation-19173313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19173313 |
| http://purl.uniprot.org/uniprot/P03987 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19173313 |
| http://purl.uniprot.org/uniprot/P01837 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19173313 |
| http://purl.uniprot.org/uniprot/P01631 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19173313 |