| http://purl.uniprot.org/citations/19174472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19174472 | http://www.w3.org/2000/01/rdf-schema#comment | "Drebrin A, one of the most abundant neuron-specific F-actin-binding proteins, is found exclusively in dendrites and is particularly concentrated in dendritic spines receiving excitatory inputs. We investigated the role of drebrin A in synaptic transmission and found that overexpression of drebrin A augmented the glutamatergic synaptic transmission, probably through an increase of active synaptic site density. Interestingly, overexpression of drebrin A also affected the frequency, amplitude and kinetics of miniature inhibitory postsynaptic currents (mIPSCs), despite the fact that GABAergic synapse density and transmission efficacy were not modified. Downregulation of drebrin A led to a decrease of both glutamatergic and GABAergic synaptic activity. In heterologous cells, drebrin A reorganized and stabilized F-actin and these effects were mediated by its actin-binding domain. Thus, drebrin A might regulate dendritic spine morphology via regulation of actin cytoskeleton remodeling and dynamics. Our data demonstrate for the first time that drebrin A modulates glutamatergic and GABAergic synaptic activities."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.033464"xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/author | "Ivanov A."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/author | "Shirao T."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/author | "Ferhat L."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/author | "Pellegrino C."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/author | "Esclapez M."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/pages | "524-534"xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/title | "Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/19174472 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19174472 |
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