| http://purl.uniprot.org/citations/19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19174516 | http://www.w3.org/2000/01/rdf-schema#comment | "Breakdown of the blood-brain barrier (BBB) is an early and significant event in CNS inflammation. Astrocyte-derived VEGF-A has been implicated in this response, but the underlying mechanisms remain unresolved. Here, we identify the endothelial transmembrane tight junction proteins claudin-5 (CLN-5) and occludin (OCLN) as targets of VEGF-A action. Down-regulation of CLN-5 and OCLN accompanied up-regulation of VEGF-A and correlated with BBB breakdown in experimental autoimmune encephalomyelitis, an animal model of CNS inflammatory disease. In cultures of brain microvascular endothelial cells, VEGF-A specifically down-regulated CLN-5 and OCLN protein and mRNA. In mouse cerebral cortex, microinjection of VEGF-A disrupted CLN-5 and OCLN and induced loss of barrier function. Importantly, functional studies revealed that expression of recombinant CLN-5 protected brain microvascular endothelial cell cultures from a VEGF-induced increase in paracellular permeability, whereas recombinant OCLN expressed under the same promoter was not protective. Previous studies have shown CLN-5 to be a key determinant of trans-endothelial resistance at the BBB. Our findings suggest that its down-regulation by VEGF-A constitutes a significant mechanism in BBB breakdown."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0808698106"xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/author | "John G.R."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/author | "Zameer A."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/author | "Argaw A.T."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/author | "Gurfein B.T."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/pages | "1977-1982"xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/title | "VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown."xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19174516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19174516 |
| http://purl.uniprot.org/citations/19174516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19174516 |
| http://purl.uniprot.org/uniprot/#_E0CZ73-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_E0CZ91-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A2A2V4-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A0A0Y0IMM4-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A0A0Y0J542-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRB6-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A8K3T2-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_B2RUP8-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_A0FKR4-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |
| http://purl.uniprot.org/uniprot/#_B2RS24-mappedCitation-19174516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19174516 |