| http://purl.uniprot.org/citations/19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19176583 | http://www.w3.org/2000/01/rdf-schema#comment | "Encapsulation of prespore cells of Dictyostelium discoideum is controlled by several intercellular signals to ensure appropriate timing during fruiting body formation. Acyl-CoA-binding protein, AcbA, is secreted by prespore cells and processed by the prestalk protease TagC to form the 34 amino acid peptide SDF-2 that triggers rapid encapsulation. AcbA is secreted when gamma-aminobutyric acid (GABA) is released from prespore cells and binds to GrlE, a G protein-coupled receptor (GPCR). Analysis of SDF-2 production in mutant strains lacking Galpha subunits and GPCRs, either as pure populations or when mixed with other mutant strains, uncovered the non-cell-autonomous roles of GrlA, Galpha4 and Galpha7. We found that Galpha7 is essential for the response to GABA and is likely to be coupled to GrlE. GrlA-null and Galpha4-null cells respond normally to GABA but fail to secrete it. We found that they are necessary for the response to a small hydrophobic molecule, SDF-3, which is released late in culmination. Pharmacological inhibition of steroidogenesis during development blocked the production of SDF-3. Moreover, the response to SDF-3 could be blocked by the steroid antagonist mifepristone, whereas hydrocortisone and other steroids mimicked the effects of SDF-3 when added in the nanomolar range. It appears that SDF-3 is a steroid that elicits rapid release of GABA by acting through the GPCR GrlA, coupled to G protein containing the Galpha4 subunit. SDF-3 is at the head of the cascade that amplifies the signal for encapsulation to ensure the rapid, synchronous formation of spores."xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.032607"xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/author | "Anjard C."xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/author | "Loomis W.F."xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/pages | "803-812"xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/title | "Steroids initiate a signaling cascade that triggers rapid sporulation in Dictyostelium."xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/19176583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19176583 |
| http://purl.uniprot.org/citations/19176583 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19176583 |
| http://purl.uniprot.org/uniprot/P34045#attribution-8AB96054448EF533C9F582145221F685 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P34042-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P34043-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P34045-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P34046-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P16894-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_Q54KV6-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_Q54R41-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_Q54VQ5-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_Q55AP1-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_Q55FI1-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |
| http://purl.uniprot.org/uniprot/#_P16051-mappedCitation-19176583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19176583 |