| http://purl.uniprot.org/citations/19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19180571 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-5 (IL-5) induction of c-Myc expression is associated with IL-5 inhibition of apoptosis in hematopoietic cells. In this study, TFalpha1 and TFalpha8 cells with stable overexpression of IL-5 receptor alpha (IL-5Ralpha) subunit in TF-1 cells, a human hematopoietic progenitor cell line which expressed low levels of IL-5Ralpha, were used to explored how IL-5 up-regulate c-Myc and the role of c-Myc in IL-5 signaling. First, we demonstrate that IL-5 induced c-Myc RNA and protein expressions, as well as activated Janus kinases (JAK1 and JAK2) and signal transducer and activator of transcription-5b (STAT5b). JAK inhibitor AG490 and c-Myc inhibitor 10058-F4, both, reduced IL-5-mediated cell proliferation in a dose- and time-dependent manner. Both, AG490 and 10058-F4, also reduced IL-5-mediated anti-apoptotic activity. Furthermore, AG490 inhibited IL-5-mediated c-Myc induction and promoter activity. We further examined the role of JAK1 and JAK2 in the induction of c-Myc expression using the CDJAK fusion proteins, which consisted of a CD16 extracellular domain, a CD7 transmembrane domain, and either JAK1 (CDJAK1) or JAK2 (CDJAK2) as intracellular domains. Simultaneous activation of JAK1 and JAK2 by anti-CD16 antibody crosslinking of CDJAK1 and CDJAK2 could induced c-Myc expression and promoter activity; AG490 inhibited CDJAK1 and CDJAK2-mediated effects. These results suggest that IL-5 induces cell proliferation and anti-apoptosis through the JAK/c-Myc pathway, and that JAK1 and JAK2 activation participate in IL-5-induced up-regulation of c-Myc."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22069"xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Lee W.H."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Lin J.Y."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Huang S.Y."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Liu F.H."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Liao W.J."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/author | "Huang H.M."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/pages | "929-936"xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/title | "JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19180571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19180571 |
| http://purl.uniprot.org/citations/19180571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19180571 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0M2-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPQ9-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_A9QVL8-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-19180571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19180571 |