| http://purl.uniprot.org/citations/19181665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19181665 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear respiratory factor 1 (NRF-1) is one of the key transcriptional activators for nuclear-coded genes involved in mitochondrial biogenesis and function as well as for many housekeeping genes. A transcriptional co-activator PGC-1 and its related family member PRC have previously been shown to interact with NRF-1 and co-activate NRF-1. We show here that NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex. Our in vitro binding experiments show that DNA-binding/dimerization domain of NRF-1 and the N-terminal half of PARP-1, which contains two Zinc fingers and the auto-modification domain, are responsible for the interaction, and that this interaction occurs with or without PARP-1 poly(ADP-ribosyl)ation (PARylation). DNA-bound NRF-1 can form a complex with PARP-1, suggesting that NRF-1 can recruit the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex to the promoter. PARP-1 can also PARylate the DNA-binding domain of NRF-1 and negatively regulate NRF-1.PARP-1 interaction. Transient transfection and chromatin immunoprecipitation experiments suggest that PARP-1 plays a role during transcriptional activation by NRF-1. Our finding identifies a new aspect of transcriptional regulation used by NRF-1."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m807198200"xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/author | "Jacobson R.H."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/author | "Anish R."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/author | "Ji P."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/author | "Hossain M.B."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/pages | "8621-8632"xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/title | "Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation."xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19181665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19181665 |
| http://purl.uniprot.org/citations/19181665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19181665 |
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