| http://purl.uniprot.org/citations/19182805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19182805 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, collectively referred to as synucleinopathies, are associated with a diverse group of genetic and environmental susceptibilities. The best studied of these is PD. alpha-Synuclein (alpha-syn) has a key role in the pathogenesis of both familial and sporadic PD, but evidence linking it to other predisposition factors is limited. Here we report a strong genetic interaction between alpha-syn and the yeast ortholog of the PD-linked gene ATP13A2 (also known as PARK9). Dopaminergic neuron loss caused by alpha-syn overexpression in animal and neuronal PD models is rescued by coexpression of PARK9. Further, knockdown of the ATP13A2 ortholog in Caenorhabditis elegans enhances alpha-syn misfolding. These data provide a direct functional connection between alpha-syn and another PD susceptibility locus. Manganese exposure is an environmental risk factor linked to PD and PD-like syndromes. We discovered that yeast PARK9 helps to protect cells from manganese toxicity, revealing a connection between PD genetics (alpha-syn and PARK9) and an environmental risk factor (PARK9 and manganese). Finally, we show that additional genes from our yeast screen, with diverse functions, are potent modifiers of alpha-syn-induced neuron loss in animals, establishing a diverse, highly conserved interaction network for alpha-syn."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.300"xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Lindquist S."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Hill K.J."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Cooper A.A."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Gitler A.D."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Chesi A."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Caldwell G.A."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Caldwell K.A."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Hamamichi S."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Rochet J.C."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Strathearn K.E."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/author | "Geddie M.L."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/pages | "308-315"xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/title | "Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity."xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/19182805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19182805 |
| http://purl.uniprot.org/citations/19182805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19182805 |
| http://purl.uniprot.org/uniprot/Q12697#attribution-91AC1E901138044D70B5CFF476D73EEA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19182805 |
| http://purl.uniprot.org/uniprot/Q27533#attribution-8344E3866AF5F0A8FFD2B37D7F1FC351 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19182805 |
| http://purl.uniprot.org/uniprot/Q27533#attribution-F48759C495A939EE04E4542268445BD2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19182805 |
| http://purl.uniprot.org/uniprot/D3YT44#attribution-8344E3866AF5F0A8FFD2B37D7F1FC351 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19182805 |