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http://purl.uniprot.org/citations/19183343http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19183343http://www.w3.org/2000/01/rdf-schema#comment"Millions of people are daily exposed to high levels of noise. Consequently, noise-induced hearing loss (NIHL) is one of the most important occupational health hazards worldwide. In this study, we performed an association study for NIHL based on a candidate gene approach. 644 Single Nucleotide Polymorphisms (SNPs) in 53 candidate genes were analyzed in two independent NIHL sample sets, a Swedish set and part of a Polish set. Eight SNPs with promising results were selected and analysed in the remaining part of the Polish samples. One SNP in PCDH15 (rs7095441), resulted in significant associations in both sample sets while two SNPs in MYH14 (rs667907 and rs588035), resulted in significant associations in the Polish sample set and significant interactions with noise exposure level in the Swedish sample set. Calculation of odds ratios revealed a significant association of rs588035 with NIHL in the Swedish high noise exposure level group. Our studies suggest that PCDH15 and MYH14 may be NIHL susceptibility genes, but further replication in independent sample sets is mandatory."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.org/dc/terms/identifier"doi:10.1111/j.1469-1809.2008.00499.x"xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Van Laer L."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Van Camp G."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Fransen E."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Bondeson M.L."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Borg E."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Konings A."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Vandevelde A."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Rajkowska E."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Sliwinska-Kowalska M."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Huyghe J."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Carlsson P.I."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Dudarewicz A."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Pawelczyk M."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/author"Wiktorek-Smagur A."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/name"Ann Hum Genet"xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/pages"215-224"xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/title"Candidate gene association study for noise-induced hearing loss in two independent noise-exposed populations."xsd:string
http://purl.uniprot.org/citations/19183343http://purl.uniprot.org/core/volume"73"xsd:string
http://purl.uniprot.org/citations/19183343http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19183343
http://purl.uniprot.org/citations/19183343http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19183343
http://purl.uniprot.org/uniprot/#_A0A087WTR6-mappedCitation-19183343http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19183343