| http://purl.uniprot.org/citations/19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19185846 | http://www.w3.org/2000/01/rdf-schema#comment | "Interactions between tumor and immune cells either enhance or inhibit cancer progression. We show here that Stat3 signaling within the tumor microenvironment induces a procarcinogenic cytokine, IL-23, while inhibiting a central anticarcinogenic cytokine, IL-12, thereby shifting the balance of tumor immunity toward carcinogenesis. Stat3 induces expression of IL-23, which is mainly produced by tumor-associated macrophages, via direct transcriptional activation of the IL-23/p19 gene. Furthermore, Stat3 inhibits NF-kappaB/c-Rel-dependent IL-12/p35 gene expression in tumor-associated dendritic cells. Tumor-associated regulatory T cells (Tregs) express IL-23 receptor, which activates Stat3 in this cell type, leading to upregulation of the Treg-specific transcription factor Foxp3 and the immunosuppressive cytokine IL-10. These results demonstrate that Stat3 promotes IL-23-mediated procarcinogenic immune responses while inhibiting IL-12-dependent antitumor immunity."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.12.018"xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Xin H."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Drake C."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Pardoll D."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Harris T."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Kortylewski M."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/author | "Kujawski M."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/pages | "114-123"xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/title | "Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment."xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/19185846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19185846 |
| http://purl.uniprot.org/citations/19185846 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19185846 |
| http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |
| http://purl.uniprot.org/uniprot/#_P01137-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |
| http://purl.uniprot.org/uniprot/#_P08253-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |
| http://purl.uniprot.org/uniprot/#_P08254-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |
| http://purl.uniprot.org/uniprot/#_P09038-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-19185846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19185846 |