| http://purl.uniprot.org/citations/19188451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19188451 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of gene expression by nuclear receptors controls the phenotypic properties and diverse biologies of target cells. In breast cancer cells, estrogen receptor alpha (ERalpha) is a master regulator of transcriptional stimulation and repression, yet the mechanisms by which agonist-bound ERalpha elicits repression are poorly understood. We analyzed early estrogen-repressed genes and found that ERalpha is recruited to ERalpha binding sites of these genes, albeit more transiently and less efficiently than for estrogen-stimulated genes. Of multiple cofactors studied, only p300 was recruited to ERalpha binding sites of repressed genes, and its knockdown prevented estrogen-mediated gene repression. Because p300 is involved in transcription initiation, we tested whether ERalpha might be trying to stimulate transcription at repressed genes, with ultimately failure and a shift to a repressive program. We found that estrogen increases transcription in a rapid but transient manner at early estrogen-repressed genes but that this is followed by recruitment of the corepressor CtBP1, a p300-interacting partner that plays an essential role in the repressive process. Thus, at early estrogen-repressed genes, ERalpha initiates transient stimulation of transcription but fails to maintain the transcriptional process observed at estrogen-stimulated genes; rather, it uses p300 to recruit CtBP1-containing complexes, eliciting chromatin modifications that lead to transcriptional repression."xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01476-08"xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/author | "Stossi F."xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/author | "Katzenellenbogen B.S."xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/author | "Madak-Erdogan Z."xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/pages | "1749-1759"xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/title | "Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1."xsd:string |
| http://purl.uniprot.org/citations/19188451 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A7D5XXG9-mappedCitation-19188451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19188451 |
| http://purl.uniprot.org/uniprot/#_A0A7D5XZ70-mappedCitation-19188451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19188451 |
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| http://purl.uniprot.org/uniprot/#_A0A7D5Y2H4-mappedCitation-19188451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19188451 |
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| http://purl.uniprot.org/uniprot/#_A0A7D6C8V1-mappedCitation-19188451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19188451 |