| http://purl.uniprot.org/citations/19189321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19189321 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleocytoplasmic shuttling transcription factor Nmp4/CIZ (nuclear matrix protein 4/cas interacting zinc finger protein) is a ubiquitously expressed protein that regulates both cytoplasmic and nuclear activities. In the nucleus, Nmp4/CIZ represses transcription of genes crucial to osteoblast differentiation and genes activated by various anabolic stimuli, including parathyroid hormone (PTH). We investigated the role of Nmp4/CIZ in the PTH-induced increase in bone by engineering mice with loss-of-function mutations in the Nmp4/CIZ gene, and treating 10-week-old female mice with anabolic doses of human PTH (1-34) at 30 microg/kg/day, 7 day/week, for 7 weeks or vehicle control. The untreated, baseline phenotype of the Nmp4-null mice between 8 and 16 weeks of age included a modest but significant increase in bone mineral density (BMD) and bone mineral content (BMC) compared to wild-type (WT) mice. Type I collagen mRNA expression was moderately elevated in the femurs of the Nmp4-null mice. The Nmp4 mutant alleles decreased body weight by 4% when expressed on a mixed background but the same alleles on a pure B6 background yielded a significant, 15% increase in body weight among the KO mice, compared to their WT controls. Hormone treatment equally enhanced BMD and BMC over vehicle-treated mice in both the WT and Nmp4-null groups but Nmp4-KO mice exhibited a significantly greater PTH-induced acquisition of femoral trabecular bone as compared to WT mice. These data support our hypothesis that Nmp4/CIZ is a transcriptional attenuator that suppresses osteoid synthesis and PTH-mediated acquisition of cancellous bone. J. Cell. Physiol. 219: 734-743, 2009. (c) 2009 Wiley-Liss, Inc."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21717"xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Heller A."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Bidwell J.P."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Robling A.G."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Childress P."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Cotte J."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/author | "Philip B.K."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/pages | "734-743"xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/title | "Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone."xsd:string |
| http://purl.uniprot.org/citations/19189321 | http://purl.uniprot.org/core/volume | "219"xsd:string |
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