| http://purl.uniprot.org/citations/1918968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1918968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1918968 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult natural mAb that were compared with 35 Ag-induced monoclonals produced during the memory response to phosphocholine (PC)-keyhole limpet hemocyanin. Both groups of monoclonals had been selected on the basis of a restricted fine specificity pattern, namely the ability to recognize PC-protein and p-nitrophenyl phosphocholine but not PC. All of the antibodies were tested for reactivity against a panel of 15 self and foreign Ag. Despite their common fine specificity as the basis for selection, 33/49 natural antibodies were poly/auto reactive whereas 0/35 Ag-induced antibodies had such poly/auto reactive properties. The natural antibodies were encoded by genes representing nine different VH families and several V kappa and V lambda families. There were a few replacement substitutions distinguishing the Ag-induced antibodies from the natural antibodies in each set; however, the most noteworthy difference was the extreme variability of CDR3 in the natural antibodies that differed in both length and amino acid sequence from each other and from Ag-induced antibodies. The results suggest that CDR3 of the H chain may play a critical role in distinguishing poly-from monospecific combining sites in natural and Ag-induced antibodies."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Rittenberg M.B."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Rittenberg M.B."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Stenzel-Poore M.P."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/author | "Stenzel-Poore M.P."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/pages | "2359-2367"xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/pages | "2359-2367"xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/title | "Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/title | "Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3."xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/1918968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1918968 |
| http://purl.uniprot.org/citations/1918968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1918968 |
| http://purl.uniprot.org/citations/1918968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1918968 |
| http://purl.uniprot.org/citations/1918968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1918968 |
| http://purl.uniprot.org/uniprot/A2NVX2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1918968 |
| http://purl.uniprot.org/uniprot/A2NVX3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1918968 |