| http://purl.uniprot.org/citations/19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19191219 | http://www.w3.org/2000/01/rdf-schema#comment | "Delta gene expression in Drosophila is regulated by proneural basic helix-loop-helix (bHLH) transcription factors, such as acheate-scute. In vertebrates, multiple Delta-like and proneural bHLH genes are expressed during neurogenesis, especially in the retina. We recently uncovered a relationship between Acheate-scute like 1 (Ascl1), Delta-like genes, and Notch in chick retinal progenitors. Here, we report that mammalian retinal progenitors are also the primary source of Delta-like genes, likely signaling through Notch among themselves, while differentiating neurons expressed Jagged2. Ascl1 is coexpressed in Delta-like and Notch active progenitors, and required for normal Delta-like gene expression and Notch signaling. We also reveal a role for Ascl1 in the regulation of Hes6, a proneurogenic factor that inhibits Notch signaling to promote neural rather than glial differentiation. Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.21848"xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Ray C.A."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Nelson B.R."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Bermingham-McDonogh O."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Reh T.A."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/author | "Hartman B.H."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/pages | "2163-2178"xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/title | "Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development."xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://purl.uniprot.org/core/volume | "238"xsd:string |
| http://purl.uniprot.org/citations/19191219 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19191219 |
| http://purl.uniprot.org/citations/19191219 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19191219 |
| http://purl.uniprot.org/uniprot/Q02067#attribution-2837FC80CF61572DAAB46F424A2DAA72 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_D3YY51-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_P56564-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_P70447-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_P70448-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J056-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VLS8-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |
| http://purl.uniprot.org/uniprot/#_A0A338P7A6-mappedCitation-19191219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19191219 |