| http://purl.uniprot.org/citations/19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19193611 | http://www.w3.org/2000/01/rdf-schema#comment | "This study was designed to establish the mechanism responsible for the increased apolipoprotein (apo) A-II levels caused by the cholesteryl ester transfer protein inhibitor torcetrapib. Nineteen subjects with low HDL cholesterol (<40 mg/dl), nine of whom were also treated with 20 mg of atorvastatin daily, received placebo for 4 weeks, followed by 120 mg of torcetrapib daily for the next 4 weeks. Six subjects in the nonatorvastatin cohort participated in a third phase, in which they received 120 mg of torcetrapib twice daily for 4 weeks. At the end of each phase, subjects underwent a primed-constant infusion of [5,5,5-(2)H(3)]L-leucine to determine the kinetics of HDL apoA-II. Relative to placebo, torcetrapib significantly increased apoA-II concentrations by reducing HDL apoA-II catabolism in the atorvastatin (-9.4%, P < 0.003) and nonatorvastatin once-(-9.9%, P = 0.02) and twice-(-13.2%, P = 0.02) daily cohorts. Torcetrapib significantly increased the amount of apoA-II in the alpha-2-migrating subpopulation of HDL when given as monotherapy (27%, P < 0.02; 57%, P < 0.003) or on a background of atorvastatin (28%, P < 0.01). In contrast, torcetrapib reduced concentrations of apoA-II in alpha-3-migrating HDL, with mean reductions of -14% (P = 0.23), -18% (P < 0.02), and -18% (P < 0.01) noted during the atorvastatin and nonatorvastatin 120 mg once- and twice-daily phases, respectively. Our findings indicate that CETP inhibition increases plasma concentrations of apoA-II by delaying HDL apoA-II catabolism and significantly alters the remodeling of apoA-II-containing HDL subpopulations."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.p800037-jlr200"xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Brousseau M.E."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Schaefer E.J."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Rader D.J."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Millar J.S."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Asztalos B.F."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Wolfe M.L."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Nartsupha C."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Diffenderfer M.R."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Digenio A.G."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/author | "Mancuso J.P."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/pages | "1456-1462"xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/title | "Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism."xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/19193611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19193611 |
| http://purl.uniprot.org/citations/19193611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19193611 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3F6-mappedCitation-19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19193611 |
| http://purl.uniprot.org/uniprot/#_A8K6C1-mappedCitation-19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19193611 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3I8-mappedCitation-19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19193611 |
| http://purl.uniprot.org/uniprot/#_B4DMZ5-mappedCitation-19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19193611 |
| http://purl.uniprot.org/uniprot/#_F4YZX8-mappedCitation-19193611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19193611 |