| http://purl.uniprot.org/citations/19193717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19193717 | http://www.w3.org/2000/01/rdf-schema#comment | "Urocortins 2 (Ucn 2), one of the corticotropin releasing factor (CRF) peptide family, is thought to be an endogenous ligand for CRF type 2 receptor (CRF-R2). We previously demonstrated that Ucn 2 is expressed in the corticotrophs of rat pituitary, and the mRNA expression and secretion of Ucn 2 in corticotrophs of rat anterior pituitary are regulated by CRF and glucocorticoids. Since CRF-R2 has been reported to be expressed on gonadotrophs of the rat pituitary, we hypothesized that pituitary Ucn 2 may control the expression and secretion of gonadotropins. Monolayer culture of rat anterior pituitary cells showed that the secretion of gonadotropins was suppressed by Ucn 2. A CRF-R2 selective antagonist, adenoviral-mediated expression of short interfering RNA against CRF-R2, and anti-Ucn 2 rabbit IgG increased the secretion and mRNA expression of gonadotropins. intraperitoneal injection of anti-Ucn 2 IgG into immature male rats significantly increased the secretion and mRNA expression of gonadotropins compared with those in normal rabbit IgG-injected rats. Daily i.p. injection of anti-Ucn 2 IgG into immature female rats induced a tendency toward earlier occurrence of menarche compared with normal rabbit IgG-injected rats. These findings suggest that pituitary Ucn 2 is involved in the regulatory mechanism of the expression and secretion of gonadotropins through its tonic and inhibitory action on gonadotrophs in a paracrine manner."xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe-08-0467"xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/author | "Nemoto T."xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/author | "Yamauchi N."xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/author | "Shibasaki T."xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/pages | "105-114"xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/title | "Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins."xsd:string |
| http://purl.uniprot.org/citations/19193717 | http://purl.uniprot.org/core/volume | "201"xsd:string |
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