| http://purl.uniprot.org/citations/19194552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19194552 | http://www.w3.org/2000/01/rdf-schema#comment | "Aldosterone has been shown to stimulate renal TGF-beta(1) expression. However, the mechanisms for aldosterone-induced TGF-beta(1) expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal regulated kinase 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone-induced TGF-beta(1) expression in rat mesangial cells. TGF-beta(1) protein in the conditioned medium released from rat mesangial cells was measured by sandwich ELISA, TGF-beta(1) mRNA expression was analyzed by Northern blotting, AP-1 DNA binding activity was measured by EMSA and the ERK1/2, JNK activity was analyzed by western blotting. Aldosterone significantly stimulated TGF-beta(1) protein production and TGF-beta(1) mRNA expression in mesangial cells in a dose-dependent manner. Aldosterone significantly increased AP-1 DNA binding activity in mesangial cells. Pre-treatment of cells with AP-1 inhibitor, curcumin, blocked aldosterone-induced AP-1 DNA binding activity as well as aldosterone-induced TGF-beta(1) production. Aldosterone increased phosphorylation of ERK1/2 and JNK in mesangial cells. Pre-treatment of cells with ERK1/2 inhibitor, PD98059, or JNK inhibitor, SP600125 significantly inhibited aldosterone-induced ERK1/2 and JNK activity and subsequently TGF-beta(1) production, respectively. We conclude that aldosterone-induced TGF-beta(1) expression in mesangial cells is regulated by the ERK1/2, JNK and AP-1 intracellular signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.org/dc/terms/identifier | "doi:10.3346/jkms.2009.24.s1.s195"xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/author | "Choi B.S."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/author | "Han J.S."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/author | "Yang C.W."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/name | "J Korean Med Sci 24"xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/pages | "S195-203"xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/title | "Aldosterone-induced TGF-beta1 expression is regulated by mitogen-activated protein kinases and activator protein-1 in mesangial cells."xsd:string |
| http://purl.uniprot.org/citations/19194552 | http://purl.uniprot.org/core/volume | "Suppl"xsd:string |
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