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| http://purl.uniprot.org/citations/19195882 | http://www.w3.org/2000/01/rdf-schema#comment | "Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD."xsd:string |
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| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/author | "Wiseman J.O."xsd:string |
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| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/author | "Eldred C.D."xsd:string |
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| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/author | "Shipley T.J."xsd:string |
| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
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| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/title | "Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration."xsd:string |
| http://purl.uniprot.org/citations/19195882 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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