| http://purl.uniprot.org/citations/19197139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19197139 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms governing hematopoietic progenitor cell mobilization are not fully understood. We report higher membrane type 1-MMP (MT1-MMP) and lower expression of the MT1-MMP inhibitor, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), on isolated circulating human CD34+ progenitor cells compared with immature BM cells. The expression of MT1-MMP correlated with clinical mobilization of CD34+ cells in healthy donors and patients with lymphoid malignancies. Treatment with G-CSF further increased MT1-MMP and decreased RECK expression in human and murine hematopoietic cells in a PI3K/Akt-dependent manner, resulting in elevated MT1-MMP activity. Blocking MT1-MMP function by Abs or siRNAs impaired chemotaxis and homing of G-CSF-mobilized human CD34+ progenitors. The mobilization of immature and maturing human progenitors in chimeric NOD/SCID mice by G-CSF was inhibited by anti-MT1-MMP treatment, while RECK neutralization promoted motility and egress of BM CD34+ cells. BM c-kit+ cells from MT1-MMP-deficient mice also exhibited inferior chemotaxis, reduced homing and engraftment capacities, and impaired G-CSF-induced mobilization in murine chimeras. Membranal CD44 cleavage by MT1-MMP was enhanced following G-CSF treatment, reducing CD34+ cell adhesion. Accordingly, CD44-deficient mice had a higher frequency of circulating progenitors. Our results reveal that the motility, adhesion, homing, and mobilization of human hematopoietic progenitor cells are regulated in a cell-autonomous manner by dynamic and opposite changes in MT1-MMP and RECK expression."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci36541"xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Dar A."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Lapidot T."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Nagler A."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Perl O."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Petit I."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Kollet O."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Resnick I."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Goichberg P."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Rosenthal E."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Avigdor A."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Naor D."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Golan K."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Hardan I."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Shivtiel S."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Kalinkovich A."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Tesio M."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Vagima Y."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/author | "Gellman Y.N."xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/pages | "492-503"xsd:string |
| http://purl.uniprot.org/citations/19197139 | http://purl.uniprot.org/core/title | "MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization."xsd:string |