| http://purl.uniprot.org/citations/19197357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19197357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19197357 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair. To improve our knowledge of transcription elongation and its coupling to TC-NER, we used the yeast library of non-essential knock-out mutations to screen for genes conferring resistance to the transcription-elongation inhibitor mycophenolic acid and the DNA-damaging agent 4-nitroquinoline-N-oxide. Our data provide evidence that subunits of the SAGA and Ccr4-Not complexes, Mediator, Bre1, Bur2, and Fun12 affect transcription elongation to different extents. Given the dependency of TC-NER on RNA Polymerase II transcription and the fact that the few proteins known to be involved in TC-NER are related to transcription, we performed an in-depth TC-NER analysis of a selection of mutants. We found that mutants of the PAF and Ccr4-Not complexes are impaired in TC-NER. This study provides evidence that PAF and Ccr4-Not are required for efficient TC-NER in yeast, unraveling a novel function for these transcription complexes and opening new perspectives for the understanding of TC-NER and its functional interconnection with transcription elongation."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000364"xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000364"xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Arino J."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Arino J."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Revuelta J.L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Revuelta J.L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Chavez S."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Chavez S."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Garcia-Rubio M.L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Garcia-Rubio M.L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Gonzalez-Aguilera C."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Gonzalez-Aguilera C."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Marin A."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Marin A."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Tous C."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Tous C."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Viladevall L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Viladevall L."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Rodriguez-Gil A."xsd:string |
| http://purl.uniprot.org/citations/19197357 | http://purl.uniprot.org/core/author | "Rodriguez-Gil A."xsd:string |