| http://purl.uniprot.org/citations/19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19197536 | http://www.w3.org/2000/01/rdf-schema#comment | "Lamellar ichthyosis is a keratinization disorder caused by TGM1, Ichthyin and several other gene mutations. A new treatment option is liarozole, which blocks the cytochrome P450 (CYP26)-mediated catabolism of endogenous all-trans retinoic acid. This study focuses on the expression of retinoid-related genes in ichthyotic epidermis before and after treatment with oral liarozole. We first compared the mRNA expression of cellular retinoic acid binding protein II (CRABPII), keratin (KRT) 2 and 4, CYP26A1 and B1, and two markers of inflammation (interleukin-1alpha and tumours necrosis factor (TNF)-alpha) in shave biopsies from 11 genetically defined, untreated patients and 12 age- and sex-matched healthy controls, finding no overt differences between the groups, besides elevated CRABPII expression. We then studied the biomarkers before and after 4 weeks of treatment with liarozole (75 or 150 mg/day), which produced a better therapeutic response in patients with Ichthyin (n=3) than in those with TGM1 (n=6) mutations. A significant decrease in the mRNA expression of KRT2 and TNF-alpha, and trends toward increased expression of KRT4 and CYP26A1 were observed in liarozole-treated patients, consistent with an increased retinoid stimulation of epidermis. However, there were no dose-related responses and the results of the immunostaining did not always parallel the mRNA findings. The results suggest that liarozole exerts a therapeutic effect in lamellar ichthyosis by mildly affecting the expression of retinoid-regulated genes in epidermis."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.org/dc/terms/identifier | "doi:10.2340/00015555-0573"xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Borgers M."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Vahlquist A."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Torma H."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Ganemo A."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Blockhuys S."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Pavez Lorie E."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "Wouters L."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/author | "van de Plassche L."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/name | "Acta Derm Venereol"xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/pages | "12-20"xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/title | "Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole."xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/19197536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19197536 |
| http://purl.uniprot.org/citations/19197536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19197536 |
| http://purl.uniprot.org/uniprot/#_B4DRV1-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_B0AZM8-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_B0AZN7-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_A8K5N5-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_G1APU8-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_P22735-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |
| http://purl.uniprot.org/uniprot/#_Q0D2K0-mappedCitation-19197536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19197536 |