http://purl.uniprot.org/citations/19199253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19199253 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the association of single nucleotide polymorphisms (SNPs) of the peptidylarginine deiminase IV (PADI4) and HLA-DRB1 shared epitope (SE) alleles with rheumatoid arthritis(RA) in a Chinese population.MethodsFour exonic SNPs of the PADI4 gene (PADI 4_89*A/G, PADI 4_90*C/T, PADI 4_92*C/G and PADI 4_104*C/T) were genotyped in 67 unrelated patients with RA and 81 healthy controls, using cDNA sequencing and T vector cloning. HLA-DRB 1*01, *04 and *10 subtypes were determined by polymerase chain reaction with sequence specific primers (PCR-SSP).ResultsThe distributions of the 4 SNPs were different in the two groups, and increased RA susceptibility was significantly associated with the minor alleles of PADI 4_89*G (P was 0.023), PADI 4_90*T (P was 0.004), PADI 4_104*T (P was 0.003), and the haplotypes carrying the 4 minor alleles (P was 0.008). HLA-DRB1 SE alleles are composed of HLA-DRB 1*0101, *0102, *0401, *0404, *0405, *0408, *0409, *0410 and *1001. Individuals carrying the SE alleles were associated with increased RA susceptibility (P was 0.002). Individuals carrying both the SE alleles and minor alleles of the 4 SNPs were more susceptible to RA than individuals carrying neither the minor SNP alleles nor the SE alleles.ConclusionThe PADI4 SNPs and haplotypes are associated with RA susceptibility in Chinese. HLA-DRB1 shared epitope is also an important risky factor for RA. There may exist certain synergistic effect between the PADI4 minor alleles and the HLA-DRB1 shared epitope."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.org/dc/terms/identifier | "doi:10.3760/cma.j.issn.1003-9406.2009.01.013"xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Fan L.Y."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Ma J.W."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Zong M."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Ding Y.Y."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/author | "Lu T.B."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/name | "Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/pages | "57-61"xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/title | "[Association of the PADI4 gene polymorphism and HLA-DRB1 shared epitope alleles with rheumatoid arthritis]."xsd:string |
http://purl.uniprot.org/citations/19199253 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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