| http://purl.uniprot.org/citations/19201837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19201837 | http://www.w3.org/2000/01/rdf-schema#comment | "Over the last several years, there has been a great deal of progress in characterizing the role of dendritic cells (DCs) in the activation and modulation of B cells. DC-secreted chemokines can induce B cell trafficking to the lymph nodes. DC-produced survival factors such as B cell-activating factor of the TNF family and a proliferation-inducing ligand have been shown to be essential for B cell maturation, but have also been implicated in class-switch recombination and B cell lymphoma survival. Recently added to this list of DC-derived factors effecting B cells is IgA-inducing protein (IGIP). In this study, we characterize production of IGIP by human DCs, and examine its capacity to induce IgA class switching and differentiation of naive B cells in vitro. Monocyte-derived DCs were cultured in vitro with TLR agonists (TLR3, 4, 5, and 9) and other factors, including CD40 ligand, GM-CSF, and IL-4 as well as the neuropeptide vasoactive intestinal peptide. Under in vitro stimulation with vasoactive intestinal peptide and CD40L, IGIP mRNA expression could be up-regulated as much as 35-fold above nonstimulated samples within 12-48 h. Naive B cells cultured with exogenous recombinant human IGIP produced IgA in greater quantities than nonstimulated controls. Finally, we demonstrate that IGIP stimulation drives the production of mu-alpha switch circles from IgM(+)IgD(+) naive human B cells, indicating its role as an IgA switch factor."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0801973"xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Goldblum R.M."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Estes D.M."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Njongmeta L.M."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Mwangi W."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Endsley M.A."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Indrikovs A.J."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Ryan M.W."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Shell E."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/author | "Ulualp S."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/pages | "1854-1859"xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/title | "Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells."xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19201837 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19201837 |
| http://purl.uniprot.org/citations/19201837 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19201837 |
| http://purl.uniprot.org/uniprot/#_A0A158RFU4-mappedCitation-19201837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19201837 |
| http://purl.uniprot.org/uniprot/#_A6NJ69-mappedCitation-19201837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19201837 |
| http://purl.uniprot.org/uniprot/A0A158RFU4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19201837 |
| http://purl.uniprot.org/uniprot/A6NJ69 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19201837 |