| http://purl.uniprot.org/citations/19202355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19202355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19202355 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitsugumin 53 (MG53) is a muscle-specific RBCC/TRIM family member predominantly localized on small vesicles underneath the plasma membrane. Upon cell-surface lesion MG53 recruits the vesicles to the repair site in an oxidation-dependent manner and MG53-knockout mice develop progressive myopathy associated with defective membrane repair. In this report, we focus on MG53-knockout cardiomyocytes showing abnormal action potential profile and a reduced K+ current density. In cDNA expression experiments using cultured cells, KV2.1-mediated currents were remarkably increased by MG53 without affecting the total and cell-surface levels of channel expression. In imaging analysis MG53 seemed to facilitate the mobility of KV2.1-containing endocytic vesicles with acidic pH. However, similar effects on the current density and vesicular mobility were not observed in the putative dominant-negative form of MG53. Our data suggest that MG53 is involved in a constitutive cycle of certain cell-surface proteins between the plasma membrane and endosome-like vesicles in striated muscle, and also imply that the vesicular dynamics are essential for the quality control of KV2.1 in cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.org/dc/terms/identifier | "doi:10.4161/chan.3.1.7571"xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.org/dc/terms/identifier | "doi:10.4161/chan.3.1.7571"xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Takeshima H."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Takeshima H."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yamazaki T."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yamazaki T."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Kangawa K."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Kangawa K."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yanagisawa T."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Yanagisawa T."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Kagaya Y."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Kagaya Y."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Nishi M."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Nishi M."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Asaumi Y."xsd:string |
| http://purl.uniprot.org/citations/19202355 | http://purl.uniprot.org/core/author | "Asaumi Y."xsd:string |