| http://purl.uniprot.org/citations/19204111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19204111 | http://www.w3.org/2000/01/rdf-schema#comment | "The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells have long been implicated in defense against candidiasis, whereas the role of Th17 cells remains controversial. IL-17 mediates inflammatory pathology in a gastric model of mucosal candidiasis, but is host protective in disseminated disease. Here, we directly compared Th1 and Th17 function in a model of OPC. Th17-deficient (IL-23p19(-/-)) and IL-17R-deficient (IL-17RA(-/-)) mice experienced severe OPC, whereas Th1-deficient (IL-12p35(-/-)) mice showed low fungal burdens and no overt disease. Neutrophil recruitment was impaired in IL-23p19(-/-) and IL-17RA(-/-), but not IL-12(-/-), mice, and TCR-alphabeta cells were more important than TCR-gammadelta cells. Surprisingly, mice deficient in the Th17 cytokine IL-22 were only mildly susceptible to OPC, indicating that IL-17 rather than IL-22 is vital in defense against oral candidiasis. Gene profiling of oral mucosal tissue showed strong induction of Th17 signature genes, including CXC chemokines and beta defensin-3. Saliva from Th17-deficient, but not Th1-deficient, mice exhibited reduced candidacidal activity. Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20081463"xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Yu J.J."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Filler S.G."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Shen F."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Conti H.R."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Edgerton M."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Stocum E."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Gaffen S.L."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Jung J.W."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Nayyar N."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Sun J.N."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Ho A.W."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Lindemann M.J."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Hai J.H."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/author | "Masso-Welch P."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/pages | "299-311"xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/title | "Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis."xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://purl.uniprot.org/core/volume | "206"xsd:string |
| http://purl.uniprot.org/citations/19204111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19204111 |
| http://purl.uniprot.org/citations/19204111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19204111 |
| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-19204111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19204111 |