| http://purl.uniprot.org/citations/19207726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19207726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19207726 | http://www.w3.org/2000/01/rdf-schema#comment | "The vaccinia virus protein, F12, has been suggested to play an important role in microtubule-based transport of intracellular enveloped virus (IEV). We found that GFP-F12 is recruited to IEV moving on microtubules but is released from virus particles when they switch to actin-based motility. In the absence of F12, although the majority of IEV remain close to their peri-nuclear site of assembly, a small number of IEV still move with linear trajectories at speeds of 0.85 μm s(-1) , consistent with microtubule transport. Using a recombinant virus expressing GST-F12, we found that the viral protein E2 interacts directly with F12. In infected cells, GFP-E2 is observed on moving IEV as well as in the Golgi region, but is not associated with actin tails. In the absence of E2L, IEV accumulate in the peri-nuclear region and F12 is not recruited. Conversely, GFP-E2 is not observed on IEV in the absence of F12. Ultra-structural analysis of ΔE2L- and ΔF12L-infected cells reveals that loss of either protein results in defects in membrane wrapping during IEV formation. We suggest that E2 and F12 function as a complex that is necessary for IEV morphogenesis prior to their microtubule-based transport towards the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1462-5822.2009.01296.x"xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1462-5822.2009.01296.x"xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Way M."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Way M."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Collinson L.M."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Collinson L.M."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Dodding M.P."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Dodding M.P."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Edwards C."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Edwards C."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Newsome T.P."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/author | "Newsome T.P."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/name | "Cell. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/name | "Cell. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/pages | "808-824"xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/pages | "808-824"xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/title | "An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/title | "An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection."xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/19207726 | http://purl.uniprot.org/core/volume | "11"xsd:string |