| http://purl.uniprot.org/citations/19208642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19208642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19208642 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I and MDA5 sense cytoplasmic viral RNA and set-off a signal transduction cascade, leading to antiviral innate immune response. The third RIG-I-like receptor, LGP2, differentially regulates RIG-I- and MDA5-dependent RNA sensing in an unknown manner. All three receptors possess a C-terminal regulatory domain (RD), which in the case of RIG-I senses the viral pattern 5'-triphosphate RNA and activates ATP-dependent signaling by RIG-I. Here we report the 2.6 A crystal structure of LGP2 RD along with in vitro and in vivo functional analyses and a homology model of MDA5 RD. Although LGP2 RD is structurally related to RIG-I RD, we find it rather binds double-stranded RNA (dsRNA) and this binding is independent of 5'-triphosphates. We identify conserved and receptor-specific parts of the RNA binding site. Latter are required for specific dsRNA binding by LGP2 RD and could confer pattern selectivity between RIG-I-like receptors. Our data furthermore suggest that LGP2 RD modulates RIG-I-dependent signaling via competition for dsRNA, another pattern sensed by RIG-I, while a fully functional LGP2 is required to augment MDA5-dependent signaling."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkp059"xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkp059"xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Cui S."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Cui S."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Hopfner K.-P."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Hopfner K.-P."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Schmidt A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Schmidt A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Lammens A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Lammens A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Rothenfusser S."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Rothenfusser S."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Lammens K."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Lammens K."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Pippig D.A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Pippig D.A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Hellmuth J.C."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Hellmuth J.C."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Kirchhofer A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/author | "Kirchhofer A."xsd:string |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19208642 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |