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| http://purl.uniprot.org/citations/19213832 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence supports the idea that insulin signaling through the insulin receptor substrate/phosphatidyl-inositol 3-kinase/Akt pathway is involved in the maintenance of beta-cell mass and function. We previously identified the insulin-response element binding protein-1 (IRE-BP1) as an effector of insulin-induced Akt signaling in the liver, and showed that the 50-kDa carboxyl fragment confers the transcriptional activity of this factor. In this investigation we found that IRE-BP1 is expressed in the alpha, beta, and delta-cells of the islets of Langerhans, and is localized to the cytoplasm in beta-cells in normal rats, but is reduced and redistributed to the islet cell nuclei in obese Zucker rats. To test whether IRE-BP1 modulates beta-cell function and insulin secretion, we used the rat insulin II promoter to drive expression of the carboxyl fragment in beta-cells. Transgenic expression of IRE-BP1 in FVB mice increases nuclear IRE-BP1 expression, and produces a phenotype similar to that of type 2 diabetes, with hyperinsulinemia, hyperglycemia, and increased body weight. IRE-BP1 increased islet type I IGF receptor expression, potentially contributing to the development of islet hypertrophy. Our findings suggest that increased gene transcription mediated through IRE-BP1 may contribute to beta-cell dysfunction in insulin resistance, and allow for the hypothesis that IRE-BP1 plays a role in the pathophysiology of type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2008-1294"xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Moore J.P."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Epstein P.N."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Villafuerte B.C."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Barati M.T."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/author | "Portillo J."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/pages | "2611-2617"xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/title | "Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/19213832 | http://purl.uniprot.org/core/volume | "150"xsd:string |
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