| http://purl.uniprot.org/citations/19217407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19217407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19217407 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand breaks (DSBs) are acutely hazardous for cells, as they can cause genome instability. DSB repair involves the sequential recruitment of repair factors to the DSBs, followed by Rad51-mediated homology probing, DNA synthesis, and ligation. However, little is known about how cells react if no homology is found and DSBs persist. Here, by monitoring a single persistent DNA break, we show that, following DNA resection and RPA recruitment, Rad51 spreads chromosome-wide bidirectionally from the DSB but selectively only on the broken chromosome. Remarkably, the persistent DSB is later fixed to the nuclear periphery in a process that requires Rad51, the histone variant H2A.Z, its SUMO modification, and the DNA-damage checkpoint. Indeed, H2A.Z is deposited close to the break early but transiently and directs DNA resection, single DSB-induced checkpoint activation, and DSB anchoring. Thus, a persistent DSB induces a multifaceted response, which is linked to a specific chromatin mark."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.01.016"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.01.016"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Kalocsay M."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Kalocsay M."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Hiller N.J."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/author | "Hiller N.J."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/pages | "335-343"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/pages | "335-343"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/title | "Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/title | "Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break."xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/19217407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19217407 |
| http://purl.uniprot.org/citations/19217407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19217407 |
| http://purl.uniprot.org/citations/19217407 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19217407 |
| http://purl.uniprot.org/citations/19217407 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19217407 |