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http://purl.uniprot.org/citations/19219602http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19219602http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The present study analyzed the polymorphisms of apoptosis-related genes and their impact on the response to chemotherapy and survival of patients with colorectal cancer.

Patients and methods

A total of 76 patients with recurrent or metastatic colorectal cancer treated with capecitabine and oxaliplatin (XELOX) combination chemotherapy were enrolled in the present study. The single nucleotide polymorphisms of 15 apoptosis-related genes (TP53, BCL2L, TNFRSF10B, AKT1, PTGS2/COX2, BID, RIPK1, FAS, FASL, caspase 3, and caspase 6-10) were determined using a PCR-RFLP assay.

Results

No significant association between the polymorphisms and the response was found for any of the genes analyzed. However, the T/T genotype of PTGS2 8473T>C (rs5275) was significantly correlated with a better progression-free survival (PFS) and overall survival (OS) when compared to the combined T/C and C/C genotype (Hazard ratio [HR] = 0.47; P value = 0.046 and HR = 0.16; P = 0.013, respectively) in a multivariate analysis adjusted for age, sex, performance status, disease status and curative resection. No association was noted between the other polymorphisms and survival.

Conclusion

The PTGS2 8473T>C polymorphism was found to be correlated with PFS and OS in patients with advanced colorectal cancer treated with XELOX chemotherapy."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.org/dc/terms/identifier"doi:10.1007/s00280-009-0947-3"xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Moon J.H."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Kim J.G."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Bae S.H."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Jun S.H."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Ryoo H.M."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Chae Y.S."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Lim K.H."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Choi G.S."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Kang B.M."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Sohn S.K."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Park I.J."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Jeon S.W."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/author"Kum Y."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/name"Cancer Chemother Pharmacol"xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/pages"953-960"xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/title"Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin."xsd:string
http://purl.uniprot.org/citations/19219602http://purl.uniprot.org/core/volume"64"xsd:string
http://purl.uniprot.org/citations/19219602http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19219602
http://purl.uniprot.org/citations/19219602http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19219602
http://purl.uniprot.org/uniprot/#_A0A0A0MRL7-mappedCitation-19219602http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19219602
http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-19219602http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19219602
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