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http://purl.uniprot.org/citations/19220911http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19220911http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Anti-PM/Scl antibodies are present in sera from patients with polymyositis (PM), systemic sclerosis (SSc), and PM/SSc overlap syndromes. The prevalence of antibodies against the 75- and 100-kDa PM/Scl proteins and their clinical associations have not been studied in SSc patients in detail so far but could provide a valuable tool for risk assessment in these patients. Furthermore, it remains speculative whether commercially available test systems detecting only anti-PM/Scl-100 antibodies are sufficient in SSc patients.

Methods

Two hundred eighty sera from SSc patients, patients with other connective tissue diseases (n = 209), and healthy blood donors (n = 50) were analyzed for the presence of anti-PM/Scl-75 and anti-PM/Scl-100 antibodies by means of line immunoblot assay. For the SSc patients, possible associations between both subsets of anti-PM/Scl antibodies with clinical and laboratory findings were studied.

Results

The determination of anti-PM/Scl reactivity revealed a diagnostic sensitivity of 12.5% and a specificity of 96.9% for SSc. Among anti-PM/Scl-positive SSc patients, 10.4% and 7.1% were positive for anti-PM/Scl-75 and anti-PM/Scl-100 antibodies, respectively. The highest prevalences of reactivity to PM/Scl were detected in diffuse SSc (19.8%) and overlap syndromes (17.6%). Patients with diffuse SSc showed mainly an anti-PM/Scl-75 response, whereas most cases of overlap syndromes were characterized by reactivity to both PM/Scl antigens. The presence of anti-PM/Scl-75/100 antibodies was associated with muscular and lung involvements as well as with digital ulcers; pulmonary arterial hypertension was found less frequently. Anti-PM/Scl-75 antibodies were detected more frequently in younger and more active patients with joint contractures. Anti-PM/Scl-100 antibodies were associated with creatine kinase elevation; however, gastrointestinal involvements were observed less frequently.

Conclusions

Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms. They are directed mainly to the PM/Scl-75 antigen. Consequently, the detection of anti-PM/Scl antibodies by tests based only on PM/Scl-100 as an antigen source may miss a relevant number of SSc patients positive for these antibodies."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.org/dc/terms/identifier"doi:10.1186/ar2614"xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Becker M."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Komorowski L."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Meyer W."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Janssen A."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Hanke K."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Burmester G.R."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Schlumberger W."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Backhaus M."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Hiepe F."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Riemekasten G."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Egerer K."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Bruckner C.S."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Dahnrich C."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Huscher D."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/author"Kill A."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/name"Arthritis Res Ther"xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/pages"R22"xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/title"Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients."xsd:string
http://purl.uniprot.org/citations/19220911http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/19220911http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19220911
http://purl.uniprot.org/citations/19220911http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19220911
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