| http://purl.uniprot.org/citations/19221030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19221030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19221030 | http://www.w3.org/2000/01/rdf-schema#comment | "Synapse formation at the neuromuscular junction (NMJ) requires an alternatively spliced variant of agrin (Z(+) agrin) that is produced only by neurons. Here, we show that Nova1 and Nova2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) agrin. Nova1/Nova2 double knockout mice are paralyzed and fail to cluster AChRs at the NMJ, and breeding them with transgenic mice constitutively expressing Z(+) agrin in motor neurons rescued AChR clustering. Surprisingly, however, these rescued mice remained paralyzed, while electrophysiologic studies demonstrated that the motor axon and synapse were functional-spontaneous and evoked recordings revealed synaptic transmission and muscle contraction. These results point to a proximal defect in motor neuron firing in the absence of Nova and reveal a previously unsuspected role for RNA regulation in the physiologic activation of motor neurons."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0813112106"xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0813112106"xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Herbst R."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Herbst R."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Burden S.J."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Burden S.J."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Fak J.J."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Fak J.J."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Fischbach G."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Fischbach G."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Jevsek M."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Jevsek M."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Mann M.A."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Mann M.A."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Ruggiu M."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/author | "Ruggiu M."xsd:string |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19221030 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |