| http://purl.uniprot.org/citations/19222710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19222710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19222710 | http://www.w3.org/2000/01/rdf-schema#comment | "Drebrin is a well-known side-binding protein of F-actin in the brain. Immunohistochemical data suggest that the peripheral parts of growing axons are enriched in the drebrin E isoform and mature axons are not. It has also been observed that drebrin E is concentrated in the growth cones of PC12 cells. These data strongly suggest that drebrin E plays a role in axonal growth during development. In this study, we used primary hippocampal neuronal cultures to analyze the role of drebrin E. Immunocytochemistry showed that within axonal growth cones drebrin E specifically localized to the transitional zone, an area in which dense networks of F-actins and microtubules overlapped. Over-expression of drebrin E caused drebrin E and F-actin to accumulate throughout the growth cone and facilitated axonal growth. In contrast, knockdown of drebrin E reduced drebrin E and F-actin in the growth cone and prevented axonal growth. Furthermore, inhibition of myosin II ATPase masked the promoting effects of drebrin E over-expression on axonal growth. These results suggest that drebrin E plays a role in axonal growth through actin-myosin interactions in the transitional zone of axonal growth cones."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2009.05993.x"xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2009.05993.x"xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Katayama M."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Katayama M."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Kojima N."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Kojima N."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Yamazaki H."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Yamazaki H."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Shirao T."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Shirao T."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Hanamura K."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Hanamura K."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Mizui T."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/author | "Mizui T."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/pages | "611-622"xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/pages | "611-622"xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/title | "Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions."xsd:string |
| http://purl.uniprot.org/citations/19222710 | http://purl.uniprot.org/core/title | "Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions."xsd:string |