| http://purl.uniprot.org/citations/19225461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19225461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19225461 | http://www.w3.org/2000/01/rdf-schema#comment | "The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats). Many pathogens have evolved the ability to avoid immune-killing by recruiting host complement regulators and several pathogens have adapted to avoid complement-mediated killing by sequestering fH to their surface. Here we present the structure of a complement regulator in complex with its pathogen surface-protein ligand. This reveals how the important human pathogen Neisseria meningitidis subverts immune responses by mimicking the host, using protein instead of charged-carbohydrate chemistry to recruit the host complement regulator, fH. The structure also indicates the molecular basis of the host-specificity of the interaction between fH and the meningococcus, and informs attempts to develop novel therapeutics and vaccines."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07769"xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07769"xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Johnson S."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Johnson S."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Roversi P."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Roversi P."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Lea S.M."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Lea S.M."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Sim R.B."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Sim R.B."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Deane J.E."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Deane J.E."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Caesar J.J."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Caesar J.J."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Kugelberg E."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Kugelberg E."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Lovett J.E."xsd:string |
| http://purl.uniprot.org/citations/19225461 | http://purl.uniprot.org/core/author | "Lovett J.E."xsd:string |