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http://purl.uniprot.org/citations/19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19225753http://www.w3.org/2000/01/rdf-schema#comment"

Aims/hypothesis

Early environmental factors and genetic variants have been reported to be involved in the pathogenesis of type 2 diabetes. The aim of this study was to investigate whether there is an interaction between birthweight and common variants in the TCF7L2, HHEX, PPARG, KCNJ11, SLC30A8, IGF2BP2, CDKAL1, CDKN2A/2B and JAZF1 genes in the risk of developing type 2 diabetes.

Methods

A total of 2,003 participants from the Helsinki Birth Cohort Study, 311 of whom were diagnosed with type 2 diabetes by an OGTT, were genotyped for the specified variants. Indices for insulin sensitivity and secretion were calculated.

Results

Low birthweight was associated with type 2 diabetes (p = 0.008) and impaired insulin secretion (p = 0.04). Of the tested variants, the risk variant in HHEX showed a trend towards a low birthweight (p = 0.09) and the risk variant in the CDKN2A/2B locus was associated with high birthweight (p = 0.01). The TCF7L2 risk allele was associated with increased risk of type 2 diabetes. Pooling across all nine genes, each risk allele increased the risk of type 2 diabetes by 14%. [corrected] Risk variants in the HHEX, CDKN2A/2B and JAZF1 genes interacted with birthweight, so that the risk of type 2 diabetes was highest in those with lower birthweight (p Conclusions/interpretationLow birthweight might affect the strength of the association of some common variants (HHEX, CDKN2A/2B and JAZF1) with type 2 diabetes. These findings need to be replicated in independent cohorts."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.org/dc/terms/identifier"doi:10.1007/s00125-009-1291-1"xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Barker D.J."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Laakso M."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Jonsson A."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Groop L.C."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Lyssenko V."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Kajantie E."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Eriksson J.G."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Osmond C."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/author"Pulizzi N."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/name"Diabetologia"xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/pages"825-829"xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/title"Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/19225753http://purl.uniprot.org/core/volume"52"xsd:string
http://purl.uniprot.org/citations/19225753http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19225753
http://purl.uniprot.org/citations/19225753http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19225753
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
http://purl.uniprot.org/uniprot/#_A0A220SZY8-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
http://purl.uniprot.org/uniprot/#_E9PFV2-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
http://purl.uniprot.org/uniprot/#_A0A0S2Z4K5-mappedCitation-19225753http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19225753
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