| http://purl.uniprot.org/citations/19228794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19228794 | http://www.w3.org/2000/01/rdf-schema#comment | "Circadian rhythms are observed in nearly all aspects of physiology and behavior. In mammals, such biological rhythms are supported by a complex network of self-sustained transcriptional loops and posttranslational modifications, which regulate timely controlled production and degradation of critical factors on a 24-h basis. Among these factors, the orphan nuclear receptor rev-erbalpha plays an essential role by linking together positive and negative regulatory loops. As an essential part of the circadian core clock mechanism, REV-ERBalpha expression shows a precisely scheduled oscillation reflecting the tight control of its production and degradation. In previous studies, we identified two alternative transcripts encoding two protein variants referred to as REV-ERBalpha1 and -alpha2. Interestingly, recent work identified structural elements present only in REV-ERBalpha1 that controls its turnover and thereby influences circadian oscillations. In the present work, we comparatively analyze the two variants and show that REV-ERBalpha2 exhibits a half-life incompatible with a circadian function, suggesting that this variant exerts different biological functions. However, our comparative study clearly indicates undistinguishable DNA-binding properties and transcriptional repression activity as well as a similar regulation mechanism. The only consistent difference appears to be the relative expression level of the two transcripts, rev-erbalpha1 being one to 100 times more expressed than alpha2 depending on tissue and circadian time. Taking this finding into consideration, we reassessed REV-ERBalpha2 turnover and were able to show that this variant exhibits a reduced half-life when coexpressed with REV-ERBalpha1. We propose that the relative expression levels of the two REV-ERBalpha variants fine-tune the circadian period length by regulating REV-ERBalpha half-life."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2008-0395"xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Laudet V."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Staels B."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Masse I."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Triqueneaux G."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Rambaud J."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/author | "Benoit G."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/pages | "630-639"xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/title | "Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation."xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/19228794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19228794 |
| http://purl.uniprot.org/citations/19228794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19228794 |
| http://purl.uniprot.org/uniprot/#_Q3UV55-mappedCitation-19228794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228794 |
| http://purl.uniprot.org/uniprot/Q3UV55 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19228794 |