| http://purl.uniprot.org/citations/19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19230833 | http://www.w3.org/2000/01/rdf-schema#comment | "The double-stranded RNA-dependent protein kinase (PKR) plays a critical role in various biological responses including antiviral defense, cell differentiation, apoptosis, and tumorigenesis. In this study, we investigated whether PKR could affect the post-translational modifications of STAT1 protein and whether these modifications regulate osteoblast differentiation. We demonstrated that PKR was necessary for the ubiquitination of STAT1 protein. The expressions of bone-related genes such as type I collagen, integrin binding sialoprotein, osteopontin, and osterix were suppressed in osteoblasts lacking PKR activity. In contrast, the expressions of interleukin-6 and matrix metalloproteinases 8 and 13 increased in PKR-mutated osteoblasts. The expression and degradation of STAT1 protein were regulated by PKR in a SLIM-dependent pathway. Inhibition of SLIM by RNA interference resulted in the decreased activity of Runx2 in osteoblasts. Stimulation of interleukin-6 expression and suppression of alkaline phosphatase activity were regulated through by SLIM-dependent pathway. However, expressions of bone-related genes and MMPs were regulated by SLIM-independent pathway. Our present results suggest that the aberrant accumulation of STAT1 protein induced by loss of PKR regulate osteoblast differentiation through both SLIM/STAT1-dependent and -independent pathways."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.02.003"xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Haneji T."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Hinode D."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/author | "Amorim B.R."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/pages | "2105-2114"xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/title | "PKR-mediated degradation of STAT1 regulates osteoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://purl.uniprot.org/core/volume | "315"xsd:string |
| http://purl.uniprot.org/citations/19230833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19230833 |
| http://purl.uniprot.org/citations/19230833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19230833 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL1-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_E9Q996-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_F7C957-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_A5JUZ1-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_P42225-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |
| http://purl.uniprot.org/uniprot/#_E9Q5F6-mappedCitation-19230833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19230833 |