| http://purl.uniprot.org/citations/19234210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19234210 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor NF-kappaB is regulated by a family of inhibitors, IkappaBs, as well as the NF-kappaB1 and NF-kappaB2 precursor proteins, p105 and p100. Although the different NF-kappaB inhibitors can all inhibit NF-kappaB in vitro, their physiological functions are incompletely understood. In this study, we demonstrate that p105 plays an important role in the regulation of T cell homeostasis and prevention of chronic inflammation. Mice lacking p105, but expressing the mature NF-kappaB1 p50, spontaneously develop intestinal inflammation with features of human inflammatory bowel disease. This inflammatory disorder occurs under specific pathogen-free conditions and critically involves T cells. Consistently, the p105-deficient mice have reduced frequency of naive T cells and increased frequency of memory/effector T cells in the peripheral lymphoid organs. Although p105 is dispensable for the production of immunosuppressive regulatory T cells, p105 deficiency renders CD4 T cells more resistant to Treg-mediated inhibition. We further show that the loss of p105 results in hyperproduction of Th17 subset of inflammatory T cells. Together, these findings suggest a critical role for NF-kappaB1 p105 in the regulation of T cell homeostasis and differentiation and the control of chronic inflammation."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803637"xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/author | "Chang M."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/author | "Lee A.J."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/author | "Fitzpatrick L."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/pages | "3131-3138"xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/title | "NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation."xsd:string |
| http://purl.uniprot.org/citations/19234210 | http://purl.uniprot.org/core/volume | "182"xsd:string |
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