| http://purl.uniprot.org/citations/19234212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19234212 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppression of an excessive systemic inflammatory response is a promising and potent strategy for treating endotoxic sepsis. Indoleamine 2,3-dioxygenase (IDO), which is the rate-limiting enzyme for tryptophan catabolism, may play a critical role in various inflammatory disorders. In this study, we report a critical role for IDO in the dysregulated immune response associated with endotoxin shock. We found that IDO knockout (IDO(-/-)) mice and 1-methyl-D-tryptophan-treated, endotoxin-shocked mice had decreased levels of the cytokines, TNF-alpha, IL-6, and IL-12, and enhanced levels of IL-10. Blockade of IDO is thought to promote host survival in LPS-induced endotoxin shock, yet little is known about the molecular mechanisms that regulate IDO expression during endotoxin shock. In vitro and in vivo, IDO expression was increased by exogenous IL-12, but decreased by exogenous IL-10 in dendritic cells and splenic dendritic cells. Interestingly, whereas LPS-induced IL-12 levels in serum were higher than those of IL-10, the balance between serum IL-12 and IL-10 following challenge became reversed in IDO(-/-)- or 1-methyl-D-tryptophan-treated mice. Our findings demonstrate that the detrimental immune response to endotoxin shock may occur via IDO modulation. Restoring the IL-12 and IL-10 balance by blocking IDO represents a potential strategy for sepsis treatment."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803104"xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Lee C.M."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Lee M.G."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Chang J.H."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Jung I.D."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Park Y.M."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Park W.S."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Seo S.K."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/author | "Jeong Y.I."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/pages | "3146-3154"xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/title | "Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock."xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19234212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19234212 |
| http://purl.uniprot.org/citations/19234212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19234212 |
| http://purl.uniprot.org/uniprot/P28776#attribution-CB7D1297FC5039138B59E75FB80B9755 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19234212 |
| http://purl.uniprot.org/uniprot/#_D3YXV1-mappedCitation-19234212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19234212 |
| http://purl.uniprot.org/uniprot/#_P28776-mappedCitation-19234212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19234212 |
| http://purl.uniprot.org/uniprot/D3YXV1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19234212 |