| http://purl.uniprot.org/citations/19234472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19234472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19234472 | http://www.w3.org/2000/01/rdf-schema#comment | "Sleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes. Studies in Drosophila have revealed molecular pathways and neural tissues regulating sleep; however, genes that maintain genetic variation for sleep in natural populations are unknown. Here, we characterized sleep in 40 wild-derived Drosophila lines and observed abundant genetic variation in sleep architecture. We associated sleep with genome-wide variation in gene expression to identify candidate genes. We independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression. Transcripts associated with sleep grouped into biologically plausible genetically correlated transcriptional modules. We confirmed co-regulated gene expression using P-element mutants. Quantitative genetic analysis of natural phenotypic variation is an efficient method for revealing candidate genes and pathways."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.330"xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.330"xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Stone E.A."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Stone E.A."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Lyman R.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Lyman R.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Harbison S.T."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Harbison S.T."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Mackay T.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Mackay T.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Carbone M.A."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Carbone M.A."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Ayroles J.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/author | "Ayroles J.F."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/pages | "371-375"xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/pages | "371-375"xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/title | "Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep."xsd:string |
| http://purl.uniprot.org/citations/19234472 | http://purl.uniprot.org/core/title | "Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep."xsd:string |