| http://purl.uniprot.org/citations/19235891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19235891 | http://www.w3.org/2000/01/rdf-schema#comment | "As a result of the progressive decrease in efficacy of drugs used to treat Parkinson's disease (PD) and the rapid development of motor complications, effective alternative treatments for PD are required. In a 6-hydroxydopamine (6-OHDA)-induced Parkinson's rat model, intracerebral peripheral blood stem cell (CD34(+)) (PBSC) transplantation significantly protected dopaminergic neurons from 6-OHDA-induced neurotoxicity, enhanced neural repair of tyrosine hydroxylase neurons through up-regulation of Bcl-2, facilitated stem cell plasticity, and attenuated activation of microglia, in comparison with vehicle-control rats. The 6-OHDA-lesioned hemi-Parkinsonian rats receiving intrastriatal transplantation of PBSCs also showed: 1) enhanced glucose metabolism in the lesioned striatum and thalamus, demonstrated by [(18)F]fluoro-2-deoxyglucose positron emission tomography (FDG-PET), 2) improved neurochemical activity as shown by proton magnetic resonance spectroscopy ((1)H-MRS), and 3) significantly reduced rotational behavior in comparison with control lesioned rats. These observations might be explained by an up-regulation of growth-associated protein 43 (GAP-43) expression because improvements in neurological dysfunction were blocked by injection of MK-801 in the PBSC-treated group. In addition, a significant increase in neurotrophic factor expression was found in the ipsilateral hemisphere of the PBSC-treated group. In summary, this protocol may be a useful strategy for the treatment of clinical PD."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.22027"xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Li K.W."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Lee Y.J."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Wang H.J."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Lin S.Z."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Su C.Y."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Liu R.S."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Peng H.F."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/author | "Shyu W.C."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/pages | "2020-2033"xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/title | "Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+) implanted-Parkinson's model."xsd:string |
| http://purl.uniprot.org/citations/19235891 | http://purl.uniprot.org/core/volume | "87"xsd:string |
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