| http://purl.uniprot.org/citations/19239415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19239415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19239415 | http://www.w3.org/2000/01/rdf-schema#comment | "The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2009.00461.x"xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2009.00461.x"xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Lopez-Lluch G."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Lopez-Lluch G."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Navas P."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Navas P."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Santos-Ocana C."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Santos-Ocana C."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "de Cabo R."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "de Cabo R."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Sinclair D.A."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Sinclair D.A."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Jimenez-Hidalgo M."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Jimenez-Hidalgo M."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Martin-Montalvo A."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Martin-Montalvo A."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Padilla S."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Padilla S."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Villalba J.M."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Villalba J.M."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Minor R.K."xsd:string |
| http://purl.uniprot.org/citations/19239415 | http://purl.uniprot.org/core/author | "Minor R.K."xsd:string |