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http://purl.uniprot.org/citations/19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19239424http://www.w3.org/2000/01/rdf-schema#comment"

Problem

Among class Ib human leukocyte antigen (HLA) molecules, HLA-E is known to be a major ligand of CD94/NKG2 receptor on natural killer (NK) cells, and to play a pivotal role in recognition of extravillous trophoblasts (EVTs) by maternal immune cells. However, it is scarcely known how HLA-E expression is regulated in EVTs.

Method of study

In this study, we investigated whether progesterone, an essential hormone in maintaining pregnancy, regulated HLA-E expression in EVT-like cell line, JEG-3. HLA-E mRNA amount in cultured JEG-3 cells was assessed by real-time PCR and cell-surface HLA-E protein was analyzed by flowcytometry.

Results

Real-time PCR showed 3.5-fold increase 1 hour after the addition of 1000 ng/ml progesterone. This response was diminished by the addition of RU486, an antagonist for progesterone receptor. Flowcytometry indicated that 1000 ng/ml progesterone slightly enhanced HLA-E expression on the surface of JEG-3.

Conclusion

These results suggest that progesterone up-regulates HLA-E expression in JEG-3 cells through the pathway mediated by progesterone receptor. Our findings might give a new insight into immunomodulatory function of progesterone at fetomaternal interface."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.org/dc/terms/identifier"doi:10.1111/j.1600-0897.2008.00684.x"xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Fujii T."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Hyodo H."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Huang Z."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Yamashita T."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Taketani Y."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Kozuma S."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Yasugi T."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Kawana K."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Matsumoto J."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/author"Nagamatsu T."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/name"Am J Reprod Immunol"xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/pages"221-226"xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/title"Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line."xsd:string
http://purl.uniprot.org/citations/19239424http://purl.uniprot.org/core/volume"61"xsd:string
http://purl.uniprot.org/citations/19239424http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19239424
http://purl.uniprot.org/citations/19239424http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19239424
http://purl.uniprot.org/uniprot/#_A0A0F7WBW2-mappedCitation-19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19239424
http://purl.uniprot.org/uniprot/#_A0A0A8LFF7-mappedCitation-19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19239424
http://purl.uniprot.org/uniprot/#_A0A0F7W1Q1-mappedCitation-19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19239424
http://purl.uniprot.org/uniprot/#_P13747-mappedCitation-19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19239424
http://purl.uniprot.org/uniprot/#_A0A7L7TM74-mappedCitation-19239424http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19239424
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