| http://purl.uniprot.org/citations/19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19240213 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuregulin-1 (NRG1) and its ErbB2/B4 receptors are encoded by candidate susceptibility genes for schizophrenia, yet the essential functions of NRG1 signaling in the CNS are still unclear. Using CRE/LOX technology, we have inactivated ErbB2/B4-mediated NRG1 signaling specifically in the CNS. In contrast to expectations, cell layers in the cerebral cortex, hippocampus, and cerebellum develop normally in the mutant mice. Instead, loss of ErbB2/B4 impairs dendritic spine maturation and perturbs interactions of postsynaptic scaffold proteins with glutamate receptors. Conversely, increased NRG1 levels promote spine maturation. ErbB2/B4-deficient mice show increased aggression and reduced prepulse inhibition. Treatment with the antipsychotic drug clozapine reverses the behavioral and spine defects. We conclude that ErbB2/B4-mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in ErbB2/B4-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0900355106"xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Lloyd K."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Roberts A.J."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Korzus E."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Stowers L."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Mayford M."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Muller U."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Halpain S."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Chamero P."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Barros C.S."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/author | "Calabrese B."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/pages | "4507-4512"xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/title | "Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19240213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19240213 |
| http://purl.uniprot.org/citations/19240213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19240213 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEA7-mappedCitation-19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19240213 |
| http://purl.uniprot.org/uniprot/#_A0A087WR33-mappedCitation-19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19240213 |
| http://purl.uniprot.org/uniprot/#_A0A087WRP2-mappedCitation-19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19240213 |
| http://purl.uniprot.org/uniprot/#_A0A140LHD8-mappedCitation-19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19240213 |
| http://purl.uniprot.org/uniprot/#_A0A140LHG5-mappedCitation-19240213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19240213 |