| http://purl.uniprot.org/citations/19246642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19246642 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-glucosylceramide has been shown to affect natural killer T cell function in models of inflammation. We, therefore, investigated the effects of different beta-glycosphingolipids, including beta-glucosylceramide, on STAT (signal transducers and activators of transcription) signaling pathways and determined whether these effects were mediated by lipid raft microdomains and/or CD1d molecules. The effects of alpha- and beta-structured ligands on the lipid raft protein flotillin-2 were studied in both natural killer T hybridoma cells and leptin-deficient mice. To determine whether CD1d was involved in the effects of the beta-glycosphingolipids, an anti-CD1d blocking antibody was used in a cell proliferation assay system. The downstream effects on the protein phosphorylation levels of STAT1, STAT3, and STAT6 were examined in both immune-mediated hepatitis and hepatoma models. The effects of beta-glycosphingolipids on the STAT signaling pathways were found to be dependent on CD1d. Lipid rafts were affected by both the dose and ratio of the beta-glycosphingolipids and the acyl chain length, and these effects were followed by downstream effects on STAT proteins. Our results show that beta-glycosphingolipids have beneficial effects in natural killer T cell-dependent immune-mediated metabolic and malignant animal models in vivo."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.080841"xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Pappo O."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Preston S."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Ilan Y."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Ben Ya'acov A."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "El Haj M."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Lalazar G."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Livovsky D.M."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/author | "Zolotarov L."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/pages | "1390-1399"xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/title | "Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2."xsd:string |
| http://purl.uniprot.org/citations/19246642 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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