| http://purl.uniprot.org/citations/19249349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19249349 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic studies have established the crucial roles of FGF signaling, FGF-induced gene expression and morphogenesis during embryogenesis. In this study, we showed that overexpressing a signaling adaptor protein, SH2B1beta, enhanced FGF1-induced neurite outgrowth in PC12 cells. SH2B1beta has previously been shown to promote nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF)-induced neurite outgrowth, in part, through prolonging NGF and GDNF-induced signaling. To delineate how SH2B1beta promotes FGF1-induced neurite outgrowth, we examined its role in FGF1-dependent signaling. Our data suggest that SH2B1beta enhances and prolongs FGF1-induced MEK-ERK1/2 and PI3K-AKT pathways. We also provided the first evidence that FGF1 induces the phosphorylation of signal transducer and activator of transcription 3 (STAT3) at serine 727 [pSTAT3(S727)] in PC12 cells. SH2B1beta enhances this phosphorylation and the expression of the immediate early gene, Egr1. Through inhibitor assays, we have further shown that MEK-ERK1/2 is required for FGF1-induced neurite outgrowth, pSTAT3(S727) and Egr1 expression. Moreover, inhibiting Rho kinase, ROCK, enhances FGF1-induced neurite outgrowth through pSTAT3(S727)-independent manner. Taken together, our results demonstrate, for the first time, that SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2009.02.009"xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Chang Y.J."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Chen S.L."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Lin W.F."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/author | "Chiu I.M."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/pages | "1060-1072"xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/title | "SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway."xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19249349 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19249349 |
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